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Profit = revenue − cost, so I'd first isolate which side is driving it (and whether it's the whole business or one segment). On revenue: price vs volume vs mix, by product and region. On cost: fixed vs variable, and whether it's input prices or efficiency. I'd also check if it's market-wide or company-specific. I structure first, then drive to the one or two branches the data points to — not boil the ocean.